Current concepts in the diagnosis and management of Parkinson's disease.
Identifieur interne : 002D90 ( Main/Exploration ); précédent : 002D89; suivant : 002D91Current concepts in the diagnosis and management of Parkinson's disease.
Auteurs : Mark Guttman [Canada] ; Stephen J. Kish ; Yoshiaki FurukawaSource :
- CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne [ 0820-3946 ] ; 2003.
Descripteurs français
- Wicri :
- geographic : Canada.
English descriptors
- KwdEn :
- Age Distribution, Antiparkinson Agents (administration & dosage), Canada (epidemiology), Disease Progression, Female, Humans, Male, Parkinson Disease (diagnosis), Parkinson Disease (drug therapy), Parkinson Disease (epidemiology), Quality of Life, Risk Assessment, Risk Factors, Severity of Illness Index, Sex Distribution, Survival Rate.
- MESH :
- chemical , administration & dosage : Antiparkinson Agents.
- geographic , epidemiology : Canada.
- diagnosis : Parkinson Disease.
- drug therapy : Parkinson Disease.
- epidemiology : Parkinson Disease.
- Age Distribution, Disease Progression, Female, Humans, Male, Quality of Life, Risk Assessment, Risk Factors, Severity of Illness Index, Sex Distribution, Survival Rate.
Abstract
Parkinson's disease is a progressive neurological disorder characterized by rest tremor, bradykinesia, rigidity and postural instability. The cause is unknown, but growing evidence suggests that it may be due to a combination of environmental and genetic factors. Treatment during the early stage of Parkinson's disease has evolved, and evidence suggests that dopamine agonist monotherapy may prevent the response fluctuations that are associated with disease progression. L-dopa therapy, however, remains the most efficacious treatment. Treatment during the advanced stage focuses on improving control of a number of specific clinical problems. Successful management of motor response fluctuations (e.g., "wearing off," on-off fluctuations, nighttime deterioration, early morning deterioration and dyskinesias) and of psychiatric problems is often possible with specific treatment strategies. Surgical treatment is an option for a defined patient population.
PubMed: 12566335
Affiliations:
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Le document en format XML
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Kish</name></author><author><name sortKey="Furukawa, Yoshiaki" sort="Furukawa, Yoshiaki" uniqKey="Furukawa Y" first="Yoshiaki" last="Furukawa">Yoshiaki Furukawa</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2003">2003</date><idno type="RBID">pubmed:12566335</idno><idno type="pmid">12566335</idno><idno type="wicri:Area/PubMed/Corpus">001454</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001454</idno><idno type="wicri:Area/PubMed/Curation">001454</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001454</idno><idno type="wicri:Area/PubMed/Checkpoint">001454</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001454</idno><idno type="wicri:Area/Ncbi/Merge">000278</idno><idno type="wicri:Area/Ncbi/Curation">000278</idno><idno type="wicri:Area/Ncbi/Checkpoint">000278</idno><idno type="wicri:doubleKey">0820-3946:2003:Guttman M:current:concepts:in</idno><idno type="wicri:Area/Main/Merge">003182</idno><idno type="wicri:Area/Main/Curation">002D90</idno><idno type="wicri:Area/Main/Exploration">002D90</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Current concepts in the diagnosis and management of Parkinson's disease.</title><author><name sortKey="Guttman, Mark" sort="Guttman, Mark" uniqKey="Guttman M" first="Mark" last="Guttman">Mark Guttman</name><affiliation wicri:level="4"><nlm:affiliation>Department of Medicine, University of Toronto, Ont, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Medicine, University of Toronto, Ont</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Kish, Stephen J" sort="Kish, Stephen J" uniqKey="Kish S" first="Stephen J" last="Kish">Stephen J. Kish</name></author><author><name sortKey="Furukawa, Yoshiaki" sort="Furukawa, Yoshiaki" uniqKey="Furukawa Y" first="Yoshiaki" last="Furukawa">Yoshiaki Furukawa</name></author></analytic><series><title level="j">CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne</title><idno type="ISSN">0820-3946</idno><imprint><date when="2003" type="published">2003</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Age Distribution</term><term>Antiparkinson Agents (administration & dosage)</term><term>Canada (epidemiology)</term><term>Disease Progression</term><term>Female</term><term>Humans</term><term>Male</term><term>Parkinson Disease (diagnosis)</term><term>Parkinson Disease (drug therapy)</term><term>Parkinson Disease (epidemiology)</term><term>Quality of Life</term><term>Risk Assessment</term><term>Risk Factors</term><term>Severity of Illness Index</term><term>Sex Distribution</term><term>Survival Rate</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Antiparkinson Agents</term></keywords><keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>Canada</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Age Distribution</term><term>Disease Progression</term><term>Female</term><term>Humans</term><term>Male</term><term>Quality of Life</term><term>Risk Assessment</term><term>Risk Factors</term><term>Severity of Illness Index</term><term>Sex Distribution</term><term>Survival Rate</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Canada</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Parkinson's disease is a progressive neurological disorder characterized by rest tremor, bradykinesia, rigidity and postural instability. The cause is unknown, but growing evidence suggests that it may be due to a combination of environmental and genetic factors. Treatment during the early stage of Parkinson's disease has evolved, and evidence suggests that dopamine agonist monotherapy may prevent the response fluctuations that are associated with disease progression. L-dopa therapy, however, remains the most efficacious treatment. Treatment during the advanced stage focuses on improving control of a number of specific clinical problems. Successful management of motor response fluctuations (e.g., "wearing off," on-off fluctuations, nighttime deterioration, early morning deterioration and dyskinesias) and of psychiatric problems is often possible with specific treatment strategies. Surgical treatment is an option for a defined patient population.</div></front></TEI><affiliations><list><country><li>Canada</li></country><region><li>Ontario</li></region><settlement><li>Toronto</li></settlement><orgName><li>Université de Toronto</li></orgName></list><tree><noCountry><name sortKey="Furukawa, Yoshiaki" sort="Furukawa, Yoshiaki" uniqKey="Furukawa Y" first="Yoshiaki" last="Furukawa">Yoshiaki Furukawa</name><name sortKey="Kish, Stephen J" sort="Kish, Stephen J" uniqKey="Kish S" first="Stephen J" last="Kish">Stephen J. Kish</name></noCountry><country name="Canada"><region name="Ontario"><name sortKey="Guttman, Mark" sort="Guttman, Mark" uniqKey="Guttman M" first="Mark" last="Guttman">Mark Guttman</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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